What type of message box?
One of the annotations or an 'app.alert'?
Sorry, an 'app.alert'
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You can create a custom dialog that can include bold text, for a static text element, for example. It's much easier to create bold blocks of text, as opposed to individual bold words within a block of text. See the execDialog method and other dialog related documentation: http://livedocs.adobe.com/acrobat_sdk/9.1/Acrobat9_1_HTMLHelp/JS_API_AcroJS.88.142.html