Those files can be safely deleted. They will be rebuilt as necessary when the project is opened. You can change the location of those saved files in the Preferences.
Auto saved files are always in the same folder as the project file. There is no way to change that.
Thanks for the valuable information. I have delete the Media Cache Files on my smaller partitioned C-drive and set the preferences to save the larger partition where the rest of Adobe's project files are sitting.
Bill thanks for sharing those articles. Good to confirm what I had thought about partitions! I avoid whenever I can, but yes sadly IT is in the driver's seat on this one...My personal system at home is another story.