Just bought FlashBuilder 4.5.1 and having the same problem here. My custom mobile skins library depends on:
C:\Program Files (x86)\Adobe\Adobe Flash Builder 4.5\sdks\4.5.0\frameworks\themes\Mobile\mobile.swc
I had to switch my project SDK from 4.5.1 to 4.5 to fix it. Sounds like a bug.
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SWC Load error indicates that the swc used does not match with the definitions present in design view or with what is present in already loaded other lirbaries. The issue is reported by the flash loader. It looks like that, your swc is compiled with a previous version of the sdk and the design view and the related definition correpsonds to another version.
The incompatability logic is not in DV. When DV tries to load all the swc details available in the project, the loading fails as the loader reports the issue. There is hardly anything, we can do here from DV. If the player reports the incompatability issue, the loader is corrupted and all further loading is ignored. So to avoid such issue, DV ignores the failed swc's and tries to proceed.
If you pass me the swc , I can give the details of the incompatability. Ideally between 4.5 and 4.5.1 there should not have been any incompatability. However your case shows there is. You can contact me at firstname.lastname@example.org