The Adobe Application Manager downloads and starts to install the update, then pauses with the message "Please close the following application to continue: Adobe Bridge CS5 (Bridge.exe)" even after a reboot with no Adobe software (apparently) running. - Windows 7 Home Premium
You probably have "Auto launch Bridge at login" turn on.
You should find Bridge icon on your taskbar tray. Right click on the Br icon, uncheck "auto start Bridge" then exit Bridge from there.
Good catch Michelle - all's OK now! Thanks for the quick response.