First: this problem is only found on one pc, a server 2008 R2 SP1. It happens only with the plugin, reader itself is not affected. It only happens with IE9, firefox is not affected. It happens for all users on this (terminal) server.
Problem: whenever I try to save a pdf I am currently viewing, reader offers to save to desktop. I always have to select a different location manually. It does not remember my last choice.
I already uninstalled reader 10.0 to install 10.1 but this did not change a thing.
To any adobe techie around: how would reader know what directory to offer?
I have the same problem. I'm using Windows 7 (x64) IE v9.0.2. It's very annoying - it always saves to the desktop, and I can't find anyplace to reset the default save directory.