And exactly? It very much tells you everything. That aside, just screaming for help without providing any solid info is probably not going to yield any results. You know, without any system info, how shoudl we even take a guess as to whyy you are receiving this message?
It looks like you have changed your preferences. Try deleting them or opening AE Preferences and assigning these folders to non-removaable drives.
If you intalled AE on a removable drive you'll have to uninstall it and re-install. It's easiest if you do not customize the install.