I have a subscription version of CS5. I had a problem when got my credit cards replaced, the payment did not process and photoshop stopped working. I logged onto Adobe and changed the details and it processed my payment. Now every time I launch photoshop Application Manager launches and asks for the serial number, which it accepts but then photoshop never opens. If I uninstall and reinstall it works but the next time I try and launch it does the same thing. I have plugins which get disabled when I reinstall, I can't do that every time I start photoshop anyways! I am told by the online helper people in India to call during business hours, but that's no good when I am at work and am not in front of my Mac.