This has been around for a few versions now and it's always bugged me but clearly not enough to do anything about it.... When you click on a page that has slices on it after opening the file, you always see the red slice guides even though the Web layer is turned off. To get rid of these guides, you have to turn the Web layer on then off again. Crazy. I've searched a fair bit but not seen anything about this.
Can anyone help?
Had the same issue and it annoys me, too. Fortunately it's a relatively annoyance, I logged it as a bug awhile back and it was just no high enough priority I guess. I double-tap '2' (shortcut for toggle web layer) to turn it clear the red guides on first-view.