My Intuos4 worked fine with LR4. However when I upgraded to LR4.1 RC, everything went to hell in a handbasket. Plus, it doesn't help to go back to LR4.0. My Wacom tablet simply will not work with LR4 any more.
PS - lots of people are having this problem.
This is certainly discouraging as I thought perhaps LR 4 might be the answer. Hmmmm.